One doctor, by the name of Su Metcalfe, may be on the verge of curing autoimmune diseases including multiple sclerosis (MS). Dr. Metcalfe is a Senior Research Associate at Cambridge Neuroscience of the University of Cambridge. Her particular area of study is application of nanotechnology to healthcare which is becoming recognized as a new era in the practice of medicine. By combining biocompatible, biodegradable nano-particles with growth factor, and targeting to sites of tissue damage, a synthetic biologically instructive niche can be created to repair tissues and/or to support cell survival in regenerative cell therapy.
With the discovery of the human genome around the turn of the century, research breakthroughs have been incredible; and more are within reach. One of the most recent breakthroughs comes out of England where Dr. Su Metcalfe is focusing on a technology called LIF (Leukemia Inhibitory Factor), which is a small blood-borne protein functioning to repair damaged tissues throughout the body (like the damaged myelin sheath of nerves in people afflicted with MS). LIF historically has been difficult to use because it had no effective way to be delivered into the body to target disease progression. However, with the use of nanotechnology and molecular engineering, LIF can now be packaged into clusters of nanoparticles; effectively delivered to the target area, passing the blood brain barrier without getting stuck in parts of the body where it could cause further or additional damage. Once these particles deliver the LIF, they naturally dissolve just like soluble stitches used to close deep wounds. According to Metcalfe, because this is, in essence, a way of reprogramming the body’s immune response, few to no side effects are expected. Although how much this will cost is yet to be determined.
“I was looking to see what controls the immune response and stops it auto-attacking us,” Metcalfe told Cambridge News. “I discovered a small binary switch, controlled by a LIF, which regulates inside the immune cell itself. LIF is able to control the cell to ensure it doesn’t attack your own body but then releases the attack when needed.” Metcalfe also said, “Nano-medicine is a new era, and big pharma has already entered this space to deliver drugs while trying to avoid the side effects,” she said. “The quantum leap is to actually go into biologics and tap into the natural pathways of the body. We’re not using any drugs; we’re simply switching on the body’s own systems of self-tolerance and repair. There aren’t any side effects because all we’re doing is tipping the balance.”
If this technique proves to work and be cost-efficient enough for our FDA to approve it, this technology could advance curing other autoimmune diseases as well as neurodegenerative diseases. Imagine curing dementia and Alzheimer’s in addition to MS, diabetes and more.
Are you hopeful?
Barbara inspires hope through mindful health and a meaningful life. By combining healthy living, spirituality, and neuroscience principles, she helps people understand how to be proactive in their health care versus reactionary in their sick care so they can feel great in their body and in their life. Her greatest wish is to never hear a person say, “I should be taking better care of myself.” To learn more and receive her FREE guide, visit Appelbaum Wellness.
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